Like it? Share it!

Scientists cure an infant of HIV. How’s your weekend?

There have been a number of huge, groundbreaking advances in the treatment of HIV in the past few years, and this weekend, scientists announced they’ve cured a child of the disease for the first time ever.

Persaud, of Johns Hopkins University Medical School, is the lead author of a report recounting the child’s treatment. The identity of the little girl, who was born to an HIV-positive woman in rural Mississippi, has yet to be released. What we do know is that she is only the second person in the world — and the first child — to be cured of HIV in its devastating 32-year history. If the case is confirmed, it is truly unprecedented.

The abstract for Persaud’s presentation (which can be found in its entirety here) provides details of the child’s treatment, which involved very early administration of antiretroviral therapy (ART), initiating treatment when the child was just 30 hours old (emphasis added):

Methods: Infant exposure to HIV was confirmed through review of maternal HIV antibody and plasma viral load tests, including HIV drug resistance testing. Infant infection was documented using standard HIV DNA polymerase chain reaction (PCR) and plasma viral load. ART administration was confirmed with medical and pharmacy records and maternal report of medication adherence. Persistence of HIV infection following treatment discontinuation was assessed using standard clinical assays that included plasma viral load, proviral DNA, and HIV antibody testing. Ultrasensitive HIV DNA (droplet digital PCR), plasma viral load (single copy) assays, and quantitative co-culture assays were done at age 24 and 26 months to further assess HIV persistence. HLA typing was done to confirm matching of the mother–infant pair.

Results: Maternal infection with wild type subtype B HIV was verified. The mother and infant shared HLA haplotypes. Infant infection was confirmed by positive HIV DNA and RNA testing on 2 separate blood samples obtained on the 2nd day of life. 3 additional plasma viral load tests (days of life 7, 12, and 20) were positive before reaching undetectable levels at age 29 days.

The child, who is now 2 and a half years old, has reportedly been off drugs for a year. Still, her blood tests continue to show no signs of a functioning virus.

The authors’ conclusions say it all: “This is the first well-documented case of functional cure in an [HIV-positive] child and suggests that very early [antiretroviral therapies] may prevent establishment of a latent reservoir and achieve cure in children.


377 notes


  1. lee6ee reblogged this from cradtr
  2. cradtr reblogged this from greyscreations
  3. thearianvoyage reblogged this from h0pelessfuckingromantiq
  4. himenozetsubou reblogged this from teamabodo
  5. phoebelamour reblogged this from iheartchaos
  6. buttercreamfrosting reblogged this from polkadopolis
  7. scumsucking reblogged this from thechelby
  8. toxic-berry reblogged this from turn-tech-goddess
  9. callmechaos reblogged this from polkadopolis
  10. thechelby reblogged this from iheartchaos
  11. polkadopolis reblogged this from lilyginnyblack
  12. chaos-jacki reblogged this from future-mrs-frost
  13. thylordshipofbutts reblogged this from shimajam
  14. makamofosho reblogged this from nyzu
  15. reaperboy reblogged this from sancabmx
  16. thevoodoodoll101 reblogged this from future-mrs-frost
  17. thenamelessbird reblogged this from thepeasantcourtier
  18. wingsofdiamonds reblogged this from redthepuppy
  19. thepeasantcourtier reblogged this from hellapetercapaldi
  20. risingstarwitch reblogged this from manateesandguardians
  21. hellapetercapaldi reblogged this from turn-tech-goddess
  22. thywinterqueen reblogged this from manateesandguardians
  23. manateesandguardians reblogged this from turn-tech-goddess
  24. turn-tech-goddess reblogged this from future-mrs-frost
  25. future-mrs-frost reblogged this from shimajam
  26. shimajam reblogged this from redthepuppy
  27. redthepuppy reblogged this from likeastormtrooper
  28. the10thsdirtylittlesecret reblogged this from gmorel1916

blog comments powered by Disqus

All profits from the sale of IHC T-shirts and stickers are donated to charity.
This month's charity is Kiva, and you can help by joining the IHC lending team.

See all IHC Reviews here

Want to submit a review for IHC and make a few bucks?
Please drop us a line and let us know what movie, game, book or TV show you want to review and we'll hold your spot. See full review guidelines here.