Naked mole rats could hold the secret to future painkillers

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Naked mole rats could hold the secret to future painkillers

From tree bark to opium, nature has provided us with some really effective pain killers. Moving from the plant to the animal kingdom, the next round of pain killers could come from the genes of the naked mole rat.

“Acidification is an unavoidable side-effect of injury,” he said. “Studying an animal that feels no pain from an acidified environment should lead to new ways of alleviating pain in humans.”

In the nose of a mammal, specialized nerve fibers are activated by acidic fumes, stimulating the trigeminal nucleus, a collection of nerves in the brainstem, which in turn elicits physiological and behavioral responses that protect the animal — it will secrete mucus and rub its nose, for example, and withdraw or avoid the acidic fumes. The researchers placed naked mole-rats in a system of cages in which some areas contained air with acidic fumes. The animals were allowed to roam freely, and the time they spent in each area was tracked. Their behavior was compared to laboratory rats, mice, and a closely related mole-rat species that likes to live in comfy conditions, as experimental controls.

The naked mole-rats spent as much time exposing themselves to acidic fumes as they spent in fume-free areas, Park said. Each control species avoided the fumes. The researchers were able to quantify the physiologic response to exposure to acidic fumes by measuring a protein, c-Fos, an indirect marker of nerve activity that is often expressed when nerve cells fire. In naked mole-rats, no such activity was found in the trigeminal nucleus when stimulated. In rats and mice, however, the trigeminal nucleus was highly activated.

The naked mole-rats’ tolerance of acidic fumes is consistent with their adaptation to living underground in chronically acidic conditions, Park said.

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